Improved Antigen Delivery Systems with PLGA Microsphere for a Single-Step Immunization

PEGylated PLGA nanoparticles for the improved delivery of doxorubicin.

UNLABELLED We hypothesize that the efficacy of doxorubicin (DOX) can be maximized and dose-limiting cardiotoxicity minimized by controlled release from PEGylated nanoparticles. To test this hypothesis, a unique surface modification technique was used to create PEGylated poly(lactic-co-glycolic acid) (PLGA) nanoparticles encapsulating DOX. An avidin-biotin coupling system was used to control pol...

a new type-ii fuzzy logic based controller for non-linear dynamical systems with application to 3-psp parallel robot

abstract type-ii fuzzy logic has shown its superiority over traditional fuzzy logic when dealing with uncertainty. type-ii fuzzy logic controllers are however newer and more promising approaches that have been recently applied to various fields due to their significant contribution especially when the noise (as an important instance of uncertainty) emerges. during the design of type- i fuz...

Antigen-Displaying Lipid-Enveloped PLGA Nanoparticles as Delivery Agents for a Plasmodium vivax Malaria Vaccine

The parasite Plasmodium vivax is the most frequent cause of malaria outside of sub-Saharan Africa, but efforts to develop viable vaccines against P. vivax so far have been inadequate. We recently developed pathogen-mimicking polymeric vaccine nanoparticles composed of the FDA-approved biodegradable polymer poly(lactide-co-glycolide) acid (PLGA) "enveloped" by a lipid membrane. In this study, we...

encapsulation of gastric tumor lysate in plga nanoparticles as antigen delivery system for anti-tumor vaccines

Single ‎A‎ssignment Capacitated Hierarchical Hub Set Covering Problem for Service Delivery Systems Over Multilevel Networks

The present study introduced a novel hierarchical hub set covering problem with capacity constraints. This study showed the significance of fixed charge costs for locating facilities, assigning hub links and designing a productivity network. The proposed model employs mixed integer programming to locate facilities and establish links between nodes according to the travel time between an origin-...